Nigel Mackman Selected Research

Atherosclerotic Plaque (Atheroma)

1/2020	Tissue factor in atherosclerosis and atherothrombosis.
1/2019	Targeting Coagulation Factor Xa Promotes Regression of Advanced Atherosclerosis in Apolipoprotein-E Deficient Mice.
1/2018	PAR2 (Protease-Activated Receptor 2) Deficiency Attenuates Atherosclerosis in Mice.
10/2012	Role of tissue factor in atherothrombosis.
5/2012	Sources of tissue factor that contribute to thrombosis after rupture of an atherosclerotic plaque.
9/2005	Postprandial elevation of tissue factor antigen in the blood of healthy adults.
8/2005	Interleukin-10 suppresses tissue factor expression in lipopolysaccharide-stimulated macrophages via inhibition of Egr-1 and a serum response element/MEK-ERK1/2 pathway.
8/2005	Regulation of tissue factor--mediated initiation of the coagulation cascade by cell surface grp78.

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Nigel Mackman Research Topics

Disease

92	Thrombosis (Thrombus) 03/2024 - 03/2003
56	Neoplasms (Cancer) 03/2024 - 02/2005
40	Inflammation (Inflammations) 02/2024 - 10/2003
27	Venous Thrombosis (Deep-Vein Thrombosis) 03/2024 - 02/2009
25	Hemorrhage 04/2024 - 04/2005
21	Infections 02/2024 - 03/2003
19	Venous Thromboembolism 04/2024 - 12/2006
17	Pancreatic Neoplasms (Pancreatic Cancer) 03/2024 - 06/2012
13	COVID-19 02/2024 - 01/2020
12	Atherosclerosis 01/2023 - 07/2002
11	Sepsis (Septicemia) 03/2023 - 08/2002
10	Endotoxemia 02/2017 - 01/2003
9	Ischemia 01/2022 - 02/2003
8	Atherosclerotic Plaque (Atheroma) 01/2020 - 08/2005
7	Rupture 01/2018 - 03/2003
6	Disseminated Intravascular Coagulation 03/2023 - 01/2003
6	Cardiovascular Diseases (Cardiovascular Disease) 01/2023 - 10/2003
6	Glioma (Gliomas) 01/2023 - 07/2006
6	Heart Failure 01/2023 - 11/2007
6	Virus Diseases (Viral Diseases) 11/2021 - 05/2008
6	Neoplasm Metastasis (Metastasis) 06/2019 - 02/2005
6	Infarction (Infarctions) 01/2018 - 02/2003
6	Reperfusion Injury 11/2017 - 02/2003
5	Fibrosis (Cirrhosis) 01/2023 - 03/2007
5	Hypoxia (Hypoxemia) 11/2017 - 03/2003
5	Sickle Cell Anemia (Hemoglobin S Disease) 11/2017 - 07/2012
4	Leukemia 04/2024 - 02/2012
4	Glioblastoma (Glioblastoma Multiforme) 01/2024 - 07/2006
4	Pulmonary Embolism 01/2023 - 01/2015
4	Thromboembolism 05/2022 - 01/2010
4	Coronary Artery Disease (Coronary Atherosclerosis) 01/2022 - 02/2012
4	Myocardial Infarction 01/2018 - 11/2007
4	Necrosis 01/2018 - 04/2009
3	Brain Neoplasms (Brain Tumor) 10/2023 - 11/2014
3	Ovarian Neoplasms (Ovarian Cancer) 03/2023 - 01/2016
3	Vascular System Injuries 01/2023 - 09/2004
3	Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome) 01/2022 - 10/2007
3	Hypertrophy 01/2021 - 11/2007
3	Breast Neoplasms (Breast Cancer) 01/2020 - 01/2010
3	Stroke (Strokes) 01/2020 - 07/2016

Drug/Important Bio-Agent (IBA)

139	Thromboplastin (Tissue Factor)IBA 04/2024 - 07/2002
37	Thrombin FDA Link 11/2023 - 02/2003
27	Proteins (Proteins, Gene)FDA Link 11/2022 - 03/2003
26	Biomarkers (Surrogate Marker)IBA 04/2024 - 03/2009
22	AnticoagulantsIBA 11/2023 - 02/2004
22	FibrinIBA 05/2021 - 01/2003
16	fibrin fragment D (D-dimer)IBA 07/2023 - 07/2012
14	LipopolysaccharidesIBA 01/2024 - 08/2002
13	Hemostatics (Antihemorrhagics)IBA 10/2023 - 03/2006
13	Peptide Hydrolases (Proteases)FDA Link 01/2021 - 02/2004
12	CytokinesIBA 02/2024 - 02/2003
9	Proteinase-Activated ReceptorsIBA 01/2019 - 02/2004
8	Histones (Histone)IBA 04/2024 - 12/2019
8	Interleukin-6 (Interleukin 6)IBA 02/2024 - 05/2004
7	Plasminogen Activators (Plasminogen Activator)IBA 04/2024 - 11/2006
7	Plasminogen Activator Inhibitor 1IBA 04/2024 - 10/2011
7	Fibrinogen (Factor I)FDA Link 10/2023 - 05/2003
7	AntithrombinsIBA 01/2023 - 12/2006
7	Messenger RNA (mRNA)IBA 11/2021 - 03/2003
7	Factor VIIa (Activated Factor VII)IBA 01/2020 - 05/2004
6	Fibrinolysin FDA Link 04/2024 - 01/2021
6	Factor Xa (Coagulation Factor Xa)IBA 01/2022 - 09/2012
6	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2015 - 10/2008
5	Cell-Free Nucleic AcidsIBA 04/2024 - 12/2019
5	Antifibrinolytic Agents (Antifibrinolytics)IBA 04/2024 - 08/2011
5	ferric chlorideIBA 01/2024 - 01/2009
5	InterferonsIBA 01/2024 - 05/2008
5	RNA (Ribonucleic Acid)IBA 07/2023 - 04/2014
5	Glycoproteins (Glycoprotein)IBA 07/2023 - 09/2005
5	IntegrinsIBA 05/2023 - 04/2013
5	Monoclonal AntibodiesIBA 01/2023 - 02/2003
5	P-SelectinIBA 01/2022 - 12/2006
5	Transcription Factors (Transcription Factor)IBA 01/2022 - 08/2002
5	LDL Receptors (LDL Receptor)IBA 01/2022 - 03/2006
5	Complement System Proteins (Complement)IBA 01/2022 - 10/2007
5	AntibodiesIBA 11/2021 - 10/2007
5	NF-kappa B (NF-kB)IBA 08/2009 - 08/2002
4	PhosphatidylserinesIBA 04/2024 - 02/2012
4	DNA (Deoxyribonucleic Acid)IBA 11/2023 - 03/2014
4	Factor XI (Plasma Thromboplastin Antecedent)IBA 01/2023 - 08/2011
4	Antiphospholipid AntibodiesIBA 01/2022 - 10/2008
4	RivaroxabanIBA 01/2022 - 01/2018
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2021 - 08/2002
4	LipidsIBA 01/2020 - 09/2005
4	PAR-2 ReceptorIBA 06/2019 - 10/2008
4	estropipate (Ogen)FDA LinkGeneric 08/2017 - 05/2003
4	PolyphosphatesIBA 04/2016 - 04/2014
4	ChemokinesIBA 01/2011 - 02/2003
3	EnzymesIBA 04/2024 - 01/2021
3	von Willebrand FactorIBA 12/2023 - 01/2021
3	Interleukin-8 (Interleukin 8)IBA 01/2022 - 07/2016
3	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 01/2022 - 09/2015
3	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2022 - 09/2015
3	Apolipoproteins E (ApoE)IBA 01/2022 - 03/2006
3	Factor Xa InhibitorsIBA 01/2022 - 01/2018
3	ApolipoproteinsIBA 01/2022 - 03/2006
3	Factor XIa (Coagulation Factor XIa)IBA 01/2020 - 04/2016

Therapy/Procedure

24	Therapeutics 01/2023 - 05/2003
8	Drug Therapy (Chemotherapy) 11/2021 - 01/2010
7	Ligation 01/2021 - 07/2002